Editorial: Danger Signals Triggering Immune Response and Inflammation

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Editorial: Danger Signals Triggering Immune Response and Inflammation

1 Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, United States, 2 Department of Microbiology Immunology, Indiana University School of Medicine, Indianapolis, IN, United States, 3 Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, United States, 4 German Academy of Transplantation Medicine, Munich, Germany, 5 Molecula...

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Danger Signals Activating the Immune Response after Trauma

Sterile injury can cause a systemic inflammatory response syndrome (SIRS) that resembles the host response during sepsis. The inflammatory response following trauma comprises various systems of the human body which are cross-linked with each other within a highly complex network of inflammation. Endogenous danger signals (danger-associated molecular patterns; DAMPs; alarmins) as well as exogeno...

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Dangerous liaisons: the role of "danger" signals in the immune response to gene therapy.

Recent studies in gene transfer suggest that the innate immune system plays a significant role in impeding gene therapy. In this review, we examine factors that might influence the recruitment and activation of the innate system in the context of gene therapy. We have adopted a novel model of immunology that contends that the immune system distinguishes not between self and nonself, but between...

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Inflammation in atherosclerosis and other conditions: a response to danger.

In the last few years atherosclerosis has been recognized as an inflammatory process. Assessment of low-grade inflammation with indexes like C-reactive protein (CRP) is considered indicative and potentially predictive for this disease. On the other hand, in a large number of clinical studies, a grade of microinflammation has been found to be associated with numerous other processes that may be ...

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Injury and immune response: applying the danger theory to mosquitoes

The insect immune response can be activated by the recognition of both non-self and molecular by-products of tissue damage. Since pathogens and tissue damage usually arise at the same time during infection, the specific mechanisms of the immune response to microorganisms, and to tissue damage have not been unraveled. Consequently, some aspects of damage caused by microorganisms in vector-borne ...

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ژورنال

عنوان ژورنال: Frontiers in Immunology

سال: 2017

ISSN: 1664-3224

DOI: 10.3389/fimmu.2017.00979